Location: GLUT demo for CFDE Summer School in Mechanistic Modeling for PBPK Transport @ 8975e3be445e / Simulation protocols.txt

Author:
David Nickerson <david.nickerson@gmail.com>
Date:
2025-08-25 22:10:27+12:00
Desc:
Adding basic documentation to use for this workspace
Permanent Source URI:
https://staging.physiomeproject.org/workspace/d5c/rawfile/8975e3be445e09f783e025526035ee8916f17eee/Simulation protocols.txt

Simulation protocols for GLUT_ss_oi.sedml:

1. As $g_i$ changes from 1 to 50 mM, the steady-state values of $v$ shift from negative (indicating transport from intracellular to extracellular) to positive (indicating transport from extracellular to intracellular).

2. As $K_{Ai}$ increases from 149.65 to 500 per fmol, a negative flow rate (from intracellular to extracellular) is observed when $g_i = g_o$, indicating thermodynamically inconsistent parameters.

3. As $\kappa_{r1}$ increases from 0.36 to 100 fmol/s, the v_max doesn't change, while the MM constant changes.